Visualization on the Upper Midwest Hub hospitals. List of hospitals include: M Health Fairview, HCMC, Health Partners, University of Nebraska, University of Iowa, Mayo Clinic, Sanford, North Memorial, Essentia, Allina, Alaska Native Medical Center.

Structure

The Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) is a clinical trials network funded by the NIH through cooperative agreements.

SIREN operates with a Hub and Spoke model. There are 16 SIREN Hubs across the the upper Midwest and Alaska. These Hubs coordinate across clinical sites (spokes) to support and advance clinical trials. Through this structure investigators are able to overcome some of the challenges associated with emergency and acute care clinical trials.

Focuses

Early Treatment: Time is an important factor in many neurological, cardiac and other emergent conditions. SIREN has built an infrastructure to support the implementation of time sensitive interventions in challenging care conditions.

Meaningful Outcomes for Patients: SIREN performs trials that can have an immediate impact on patient care. Therefore, primary outcomes are patient oriented rather than disease oriented. Outcomes are assessed in the long-term to get a full scope of the effect on patients. SIREN holds a commitment to giving the opportunity for clinical trials to a diverse group of patients.

Efficiency: The Hub and Spoke model allows for there to be parallel studies running at the same time. Comprehensive study management allows for the reduction of regulatory burden on each individual site.

Collaboration: Collaboration is a key factor in the sciences. Through collaboration we are able to innovate the clinical trials.

Transforming the Clinical Trial Enterprise: SIREN has developed a methodological tool kit to help pair the right study structure with the right study question.

Meet the MN Hub